Tumor dormancy in population of cancer stem cells: gene interactions by bioinformatics

Introduction: Cancer stem cells (CSC) correspond to a small population of cells tumor with the ability to remain hidden. This contributes strongly to the resistance to antitumor therapies, the occurrence of relapse and metastasis. Objective: Inter relate the gene interactions networks of tumor dormancy (TD) and CSC. Methods: Genetic interaction networks of CSC and DT were identified in the Gene Cards® database. The maps of genomic interactions were performed using the software STRING 10.0. The cluster analysis of the genes was performed in the SPSS® Statistic 18.0.DT network genes present in the CSC were identified. Dormancy markers were analyzed for the interactions performed in both networks. Results: 386 and42genes belonging to the CSC and TD networks, respectively, were identified. TP53, MYC, AKT1, CTNNB1, JUN andSTAT3 genes were considered the leading of the CSC. The leading genes of TD were AKT1,CDK2, MAP2K4, PCNA, VEGFA and MCM2. The dormancy presented 12 genes common to CSC, with prominence for AKT1, considered leader in both conditions. All of the dormancy markers were identified in the CSC network, with between 8and 13 interactions performed per gene. Conclusion: Twelve genes common to the TD and CSC networksratify the interrelation between them.