Solubility and Bioavailability Enhancement of poorly Water Soluble Drug Lercanidipine

The aim of the study was to enhance the solubility and dissolution rate of poorly water soluble drug lercanidipine by solid dispersion technique. Solid dispersion of lercanidipine was prepared by solvent evaporation and kneading technique by using polymer PVP K30 in 1:1, 1:3, 1:5 drug: polymer ratio respectively. Drug excipient compatibility study indicates that there is no interaction between the excipient and the drug. Total six batches were prepared and subjected to evaluation parameters. Prepared solid dispersion of lercanidipine was evaluated for solubility, drug content, in vitro drug release and short term stability studies. Solubility study of all the SD formulation’s shows increased in solubility of drug as compare to pure lercanidipine and physical mixture. It was observed that as the concentration polymer increases the drug solubility also increases. The in vitro dissolution profile of all the formulation was rapid and all the formulation showed more than drug 50% release within 30 min. The optimized formulation of F6 prepared with PVP K30 by kneading method containing drug to polymer in a ratio of 1:5 was consider as the optimized formulation with respect to drug content, solubility and in vitro drug release pattern for 60 min. Formulation F6 showed highest 99.11% drug release at the end of 60 min. Optimized formulation F6 was found to be stable during the stability studies for 3 month indicating good stability of the formulation.