Study the complications of accumulatediron in the tissue and glands in patients with major β-thalassemia

In the present study, an attempt is carried out to estimate the level of sex hormone in thalassemia major patients where. The level of these compounds will indicate the risk of tissue damage caused by oxidative stress and iron overload in thalassemia patients. Thirty five Iraqi patients with major thalassemia were participated in the present study. Their age range was 2-12 years old. In other hand Thirty five apparently healthy children were selected as control group. Serum hormones (Leutinizing hormone (LH), Follicle-stimulating hormone (FSH), Testosterone, Estradiol (E2), Prolactine (PRL) were measured using ready for use ELISA kits supplied by Monobind®, Serum levels of iron was measured spectrophotometrically. The results showed significant increase (p<0.05) in iron level in patients with thalassemia as compared with their control group, in the other hand the results showed significant decrease (p<0.05) in all sex hormone(FSH&TEST.) of thalassemic patients in comparing with healthy control group except LH&PRO. Concentration, which on significantly changing (p˃0.05) in those patients when comparing with the control group. It can be concluded that Iraqi thalassemic patients are at high risk for iron overload and iron-induced toxicities. These patients are prone to tissue injury caused by collection of iron in tissue.