Evaluation of antifungal activity of the hydroalcoolic extract of Pereskia aculeata miller leaves in Candida spp

The genus Candida has about 200 species, of which 17 are of clinical interest in the most diverse environments and body nichesIn this context, medicinal plants have been tested to combat various pathologies, for example, for candidiasis, the Pereskia aculeata Miller with different therapeutic effects can be highlighted. The aim of this study was to evaluate the antifungal activity of Pereskia aculeata Miller extract in Candida albicans, Candida tropicalis and Candida albicans ATCC 90028 strains. Therefore, the P. aculeata plant was collected from the Biodiversity site located at the Massif of Baturité in the city of Mulungu-CE. The extracts of P. aculeata Miller leaves were prepared with 70% alcohol and distilled water. The strains were seeded in 96-well U-well microtiter plates containing RPMI 1640. The strains used in the antifungal test came from different strains of body sites.It was verified in the study that the hydroalcoholic extract of P. aculeata demonstrated inhibitory activity against the strains used, where the concentration of the extract that inhibited the growth of the strains varied between 12.5 and 25%. The study demonstrated through the microdilution technique in the broth that there is inhibition of growth in some species of the genus Candida using the extract of P. aculeata.