Biosynthesis of silver and zinc oxide nanoparticles and evaluation of their in-vitro anti cancer property against acute myeloid leukemia (tph1) cells

In the present study, the yeast Pichia fermentans was isolated from fruit waste and identified and utilized for the biosynthesis of silver (Ag NPs) and Zinc oxide (ZnO NPs) nanoparticles. The synthesized nanoparticles were characterized by X-Ray Diffraction, Transmission Electron Microscopy, Energy Dispersive Spectroscopy and Fourier Transform Infrared Spectroscopy. The characterization study revealed the maximum size of Ag NPs was 98.6 nm and ZnO NPs was 140 nm. The nanoparticles were evaluated for their anticancer activity against Acute Myeloid Leukemia cells (THP1) cells. The concentration required to make 50% cell death was observed at 500µg/ml for the silver nanoparticles whereas ZnO NPs showed a proportionate increased cytotoxicity at higher concentration.