The association finasteride & blend-containing growth factors by bacterial reverse mutation assay

The psychologically impactful hair loss caused by a hereditary pattern, known as androgenetic alopecia (AGA), can occur in men as in women. Among medicines, finasteride has been used in association with blend-containing growth factors. The objective of this work was to evaluate the effects of the association between finasteride & blend-containing growth factors using a bacterial reverse mutation assay. Both compounds or in the mixture were subjected to TA97a, TA98, TA100, and TA102 with (+S9) and without (-S9) metabolic activation, using different concentration and combinations. Finasteride (5 mg/plate) showed to be non-toxic to TA100 strain, but not the blend when exposed at concentrations of 2.5 mg/plate. Finasteride + blend association showed to be non-mutagenic in the absence (-S9) of metabolic activation. In the presence (+S9) of metabolic activation, the association was mutagenic in a dose-dependently manner. Under safe concentrations of blend obtained through serial dilution, the association was mutagenic only to TA98 strain (+S9). Finasteride isolated showed to be safe. Safe levels of the blend were found in the absence as in the presence of metabolic activation face to S. Typhimurium TA97a, TA98, TA100, and TA102 strains. Even under safe blend concentration, the association induced reverse mutation on TA98 having the finasteride-ω-oic-acid as a suggestive candidate.